For blood cancer patients receiving a stem cell transplant from an unrelated donor, survival rates appear to be similar regardless of whether the stem cells were collected from the blood or from the bone marrow, according to results from a recent randomized Phase 3 trial.
However, transplants using stem cells from the blood were associated with a higher rate of chronic graft-versus-host disease, a common transplant-related complication.
Dr. Claudio Anasetti of the Moffitt Cancer Center in Tampa, Florida, presented the…
An oral formulation of Estybon shows activity and is safe in patients with myelodysplastic syndromes, according to results of a Phase 1 study.
The study investigators found that the optimal dose for oral Estybon was 560 mg twice daily for two weeks of a three-week treatment cycle. The most common observed side effects were problems involving urination, such as painful urination and blood in the urine.
The findings were presented during a poster session at the 2011 American Society of…
Researchers from the United States and Spain recently found that lower-risk myelodysplastic syndromes patients may benefit from early treatment with a certain kind of stem cell transplant.
Specifically, the patients benefited from donor stem cell transplants without T-cells, a type of white blood cell.
Over 60 percent of patients experienced survival times greater than five years, and the rate of graft-versus-host disease, a common transplant-related complication, was low.
According to the researchers, these findings support the use of transplantation without…
Treatment with Sprycel yields low response rates and high rates of progression to leukemia in patients with higher-risk myelodysplastic syndromes, according to results from a recent small Phase 2 study.
The study authors found that 50 percent of patients with myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) progressed to leukemia.
However, the results also showed that patients who responded or maintained stable disease survived significantly longer than those who did not respond. The study investigators suggested that Sprycel could be…