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[ by Gillian Losh | Oct 21, 2009 3:43 pm | No Comment ]
Valproic Acid May Enhance Efficacy Of Vidaza For Myelodysplastic Syndromes

A combination therapy of Vidaza (azacitidine) and valproic acid (Depakene) may be more effective than Vidaza alone for the treatment of myelodysplastic syndromes (MDS), according to a Phase 2 study published in the journal Clinical Cancer Research.

Valproic acid is commonly used to reduce seizures in epilepsy patients and to treat bipolar disorder. It has recently become of interest as a possible treatment for blood- and bone marrow-related cancers like MDS.

Previous studies have shown that two classes of drugs, hypomethylating agents, which include Vidaza, and histone deacetylase inhibitors, which…

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